São Sebastião (Portuguese for "Saint Sebastian") may refer to:
São Sebastião is a station on the Blue Line and the Red Line of the Lisbon Metro. It is located in the parish of São Sebastião da Pedreira.
Media related to Metro station São Sebastião (Lisboa) at Wikimedia Commons
São Sebastião (Portuguese for Saint Sebastian) is a parish in the municipality of Ponta Delgada in the Azores. The population in 2011 was 3,953, in an area of 3.34 km². The parish is part of the downtown area of Ponta Delgada. Until June 30, 2003, the parish was known as Matriz (Ponta Delgada).
São Sebastião do Passé is a municipality in the state of Bahia in the North-East region of Brazil.